Antibody-Drug Conjugates: Fundamentals, Drug Development, by Kenneth J. Olivier Jr., Sara A. Hurvitz

By Kenneth J. Olivier Jr., Sara A. Hurvitz

Providing sensible and confirmed strategies for antibody-drug conjugate (ADC) drug discovery good fortune in oncology, this booklet is helping readers increase the drug security and healing efficacy of ADCs to kill unique tumor cells.

• Discusses the fundamentals, drug supply concepts, pharmacology and toxicology, and regulatory approval strategies
• Covers the behavior and layout of oncology medical trials and using ADCs for tumor imaging
• Includes case reports of ADCs in oncology drug development
• Features contributions from highly-regarded specialists at the frontlines of ADC examine and development

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Extra resources for Antibody-Drug Conjugates: Fundamentals, Drug Development, and Clinical Outcomes to Target Cancer

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Science (New York, NY) 1977;198:1056–63. Williams AF, Galfre G, Milstein C. Analysis of cell surfaces by xenogeneic myeloma‐hybrid antibodies: differentiation antigens of rat lymphocytes. Cell 1977;12:663–73. Milstein C, Lennox E. The use of monoclonal antibody techniques in the study of development cell surfaces. Current Topics in Developmental Biology 1980;14:1–32. Ritz J, Schlossman SF. Utilization of monoclonal antibodies in the treatment of leukemia and lymphoma. Blood 1982;59:1–11. Macek C Monoclonal antibodies: key to a revolution in clinical medicine.

Alternatively, increasing its hydrophilic nature, for example, via charged groups, may decrease the rate of transmembrane transfer and thereby increase cellular retention [47, 48]. 6), and a second functional group capable of reacting with an appropriate complementary functional group of the cytotoxic payload. This approach is the one taken in making ADCs using the maytansinoid platform, as exemplified by ado-trastuzumab emtansine [5, 26, 49]. 6). This approach is exemplified by ADCs such as brentuximab vedotin using the auristatin platform [4, 5, 31].

The design goal is to add the potent tumor cell-killing mechanism afforded by the payload, while retaining all the favorable properties of the antibody in terms of in vivo pharmacokinetics and biodistribution, together with any intrinsic biologic activity and immunologic properties. It is beyond the scope of this chapter to discuss the properties of the cell surface target molecule, but suffice to say that selecting the right target, and matching the design of the ADC to the properties of the target, is vital to the creation of an effective therapeutic agent.

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