By Kenneth J. Olivier Jr., Sara A. Hurvitz
Providing sensible and confirmed strategies for antibody-drug conjugate (ADC) drug discovery good fortune in oncology, this booklet is helping readers increase the drug security and healing efficacy of ADCs to kill unique tumor cells.
• Discusses the fundamentals, drug supply concepts, pharmacology and toxicology, and regulatory approval strategies
• Covers the behavior and layout of oncology medical trials and using ADCs for tumor imaging
• Includes case reports of ADCs in oncology drug development
• Features contributions from highly-regarded specialists at the frontlines of ADC examine and development
Read Online or Download Antibody-Drug Conjugates: Fundamentals, Drug Development, and Clinical Outcomes to Target Cancer PDF
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Extra resources for Antibody-Drug Conjugates: Fundamentals, Drug Development, and Clinical Outcomes to Target Cancer
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Alternatively, increasing its hydrophilic nature, for example, via charged groups, may decrease the rate of transmembrane transfer and thereby increase cellular retention [47, 48]. 6), and a second functional group capable of reacting with an appropriate complementary functional group of the cytotoxic payload. This approach is the one taken in making ADCs using the maytansinoid platform, as exemplified by ado-trastuzumab emtansine [5, 26, 49]. 6). This approach is exemplified by ADCs such as brentuximab vedotin using the auristatin platform [4, 5, 31].
The design goal is to add the potent tumor cell-killing mechanism afforded by the payload, while retaining all the favorable properties of the antibody in terms of in vivo pharmacokinetics and biodistribution, together with any intrinsic biologic activity and immunologic properties. It is beyond the scope of this chapter to discuss the properties of the cell surface target molecule, but suffice to say that selecting the right target, and matching the design of the ADC to the properties of the target, is vital to the creation of an effective therapeutic agent.