Artificial and Reconstituted Membrane Systems by Jacqueline A. Reynolds (auth.), J. R. Harris, A.-H. Etémadi

By Jacqueline A. Reynolds (auth.), J. R. Harris, A.-H. Etémadi (eds.)

This number of eleven chapters is dedicated to a survey of man-made and reconsti­ tuted membrane structures. those are basic issues and components of significant present significance in membrane biochemistry. additionally they relate good to the founding suggestion of this sequence, specifically, to provide experiences that steadily paintings towards and supply us with an "integrated view of the phone. " during this quantity, it's the program of quite a lot of physiochemical and biochemi­ cal concepts to the examine of membrane lipids and proteins which serves to illustrate the numerous growth that has been made during this box over the last 25 years. From the certainty of simplified man made structures, it really is was hoping that it'll finally be attainable to realize a extra actual realizing of common organic membranes, in all their variety. This ebook is a suitable successor to quantity thirteen of the sequence, which offers with fluorescence experiences on organic membranes. certainly, the current bankruptcy through Lesley Davenport and associates used to be initially due for inclusion in quantity thirteen, yet has been held over for inclusion during this quantity, the place it integrates remarkably good with the opposite themes. The super diversified and engaging contents of this quantity at the moment are in short defined. In bankruptcy I, Jacqueline A. Reynolds and Darrell R. McCaslin pres­ ent a pertinent survey of the interplay of detergents with membrane lipids and proteins, including an evaluation of the reconstitution process.

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Artificial and Reconstituted Membrane Systems

This number of eleven chapters is dedicated to a survey of man-made and reconsti­ tuted membrane platforms. those are basic topics and parts of significant present value in membrane biochemistry. in addition they relate good to the founding thought of this sequence, specifically, to give experiences that steadily paintings towards and supply us with an "integrated view of the mobilephone.

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Typical 3Ip_NMR spectra of aqueous dispersions of phospholipids in (a) bilayer, (b) micellar, and (c) hexagonal-II configurations. around a director axi~ consisting of a low-field shoulder and high-field peak. , 1975, 1981; Seelig and Gally, 1976). Such studies indicate that molecules with their long axis perpendicular to the magnetic field contribute to the high-field peak and molecules with a parallel orientation correspond to resonances at a position in the shoulder region, and that the director axis coincides with the bilayer normal about which the phosphate segment rotates.

1968, Protein denaturation. Adv. Protein Chem. 23:121-282. , 1970, Protein denaturation. Adv. Protein Chem. 24:2-93. , 1980, The Hydrophobic Effect, Wiley, New York. , and Reynolds, J. , 1976, Characterization of membrane proteins in detergent solutions. Biochim. Biophys. Acta 457:133-170. , 1891, Ueber die Capillaritatsconstanten organischer Stoffe in wassenigen Losungen. Liebig's Ann. Chem. 265:27-55. , and Reynolds, J. , 1984, Phospholipid vesicle formation using nonionic detergents with low monomer solubility.

Preliminary studies in this laboratory using the Ca2 + ATPase from sarcoplasmic reticulum substantiate this view. Detergents in Membrane Reconstitution 5. 23 SOME CONCLUDING COMMENTS Our understanding of the mechanistic processes involved in lipid-proteindetergent interactions is far from complete, and there are, unfortunately, no "cookbook recipes" for reconstitution of lipid vesicles and intrinsic membrane proteins. However, years ofresearch in fields such as colloid and surface chemistry, protein structure and function, chemical equilibria, and kinetics provide a fundamental body of knowledge on which one can build.

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