Asymmetric Synthesis of Nitrogen Heterocycles by Jacques Royer, H. P. Husson

By Jacques Royer, H. P. Husson

Right here, all features of the subject are provided in a compact demeanour. The ebook is obviously established, and divided into sections -- uneven synthesis of heterocycles containing just one nitrogen and that of these with a couple of nitrogen as a heteroatom -- such that the mandatory info might be chanced on at a look. The overseas group of authors presents very important experimental techniques, together with business applications.Essential for man made chemists in pharmaceutical and agrochemical chemistry.

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Asymmetric Synthesis of Nitrogen Heterocycles

Right here, all elements of the subject are offered in a compact demeanour. The ebook is obviously established, and divided into sections -- uneven synthesis of heterocycles containing just one nitrogen and that of these with multiple nitrogen as a heteroatom -- such that the required info can be chanced on at a look.

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Eds) (2008) Comprehensive Organic Chemistry, Vol. 1, Elsevier. 45 46 1 Asymmetric Synthesis of Three- and Four-Membered Ring Heterocycles 3 Hodgkinson, T. J. and Shipman, 4 5 6 7 8 9 10 11 12 13 14 15 16 M. (2001) Tetrahedron, 57, 4467. Kasai, M. and Kono, M. (1992) Synlett, 778. Schirmeister, T. (1999) Biopolymers, 51, 87. Stapley, E. , Miller, A. , Hernandez, S. and Mata, J. M. (1971) J. , 24, 42–47. Molinski, T. F. and Ireland, C. M. (1988) J. Org. , 53, 2103–5. Gabriel, S. (1888) Chem. , 21, 1049.

O O R OH H2, (R )-Binap Bn OH (1) MsCl, TEA R R R N R Ruthenium salt R (2) BnNH2 Iodomethylation of enantiopure α-(dibenzyl)aminoaldehydes by means of samarium/diiodomethane under mild conditions gave optically active aminoiodohydrins, as precursors of azetidinium tetrafluroborate salts. These salts are versatile building blocks that can be transformed into aminoepoxides, 1,3-oxazolidines, or turned into N-benzyl-hydroxyazetidines by simple hydrogenolysis [112]. HCO2H O R Bn2N Sm/CH2I2 H H3O+ H R H OH R I AgBF4 Bn2N H de 80% Bn2N ⊕ OH BF4 R Pd/MeOH Bn R′NH2 OH N H O R CH2Cl2 Bn2N N R′ H 50–62% Ring closure of aminoallenes has attracted much attention in the development of stereoselective processes to five- or six-membered nitrogen-containing heterocycles.

Kim, B. , Bae, S. , So, S. , Yoo, H. , Chang, S. , Lee, J. H. and Kang, J. (2001) Org. , 3, 2349–51. (a) Osborn, H. M. , Cantrill, A. , Sweeney, J. B. and Howson, W. (1994) Tetrahedron, 35, 3159–62; (b) Osborn, H. M. I. and Sweeney, J. B. (1994) Synlett, 145–47. ,Chung, J. K. K. and Tang, N. , 34, 6513–16. Shaw, K. , Luly, J. R. and Rapoport, H. (1985) J. Org. , 50, 4515–23. , van der Marel, G. A. and van Boom, J. H. , 33, 3013–16; (b) Baldwin, J. , Farthing, C. , Russell, A. , Schonfield, C. J.

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