By P. N. Preston
The Chemistry of Heterocyclic Compounds, for the reason that its inception, has been well-known as a cornerstone of heterocyclic chemistry. each one quantity makes an attempt to debate all facets – houses, synthesis, reactions, physiological and business importance – of a selected ring method. to maintain the sequence up to date, supplementary volumes protecting the new literature on each one person ring procedure were released. Many ring platforms (such as pyridines and oxazoles) are handled in exact books, every one including separate volumes or elements facing assorted person themes. With all authors are famous experts, the Chemistry of Heterocyclic Chemistry is taken into account all over the world because the crucial source for natural, bioorganic, and medicinal chemists.
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Additional resources for Benzimidazoles and Cogeneric Tricyclic Compounds, Part 2 (The Chemistry of Heterocyclic Compounds, Volume 40)
Hydrate. I Solvent of crystallization not specified. Dihydrate. Hemihydrate. Acetic acid solvate. " Yield not quoted. %)]. 96) by the solvent. 91) in ethanolic hydrochloric acid can likewise be r a t i o n a l i ~ e d in ~ . terms ~ ~ of initial anil formation followed by cyclization to and in situ oxidation of a tetrahydro- 1H-pyrrolo[1,2-a]benzimidazole intermediate [cf. 97)]. 9). 88)p9provide evidence for the intermediacy of 2,3,3a,4-tetrahydro-l H-pyrrolo[ 1,2-a]benzimidazoles in the presumed nitrene-initiated cyclizations of N-(2-azidophenyl)pyrroIidines leading to 2,3-dihydro- 1H-pyrrolo[ 1,2-a]benzimidazole derivatives (see before).
E - 71 50 quant. p. ("C) b b b b d Benzene-n-hexane b - Cyclohexane Ether -b 52 53 54 54 51 58 58 58 58 58 58 41 51 - b 51 47 48 48 50 49 41 49 49 48 48 Ref. 8. 78; R' = H, R2= NO,, 61 33 67 68 70 13 32 16 78 quant. quant. ) 255-260 196-198 190 148 182 - - 224 148 134 96 138 114 115 239 Ethyl acetate Ethyl acetatelight petroleum (b. p. 60-80") -b -b -b -b -b -b 62 62 65 65 58 61 61 62 62 62 62 62 63 58 58 58 58 Solvent of crystallization not specified. Colorless needles. Purified by sublimation.
82 N(4)CH Signals are sharp singlets unless otherwise specified as: d = doublet; t = triplet; q = quartet; m = multiplet. A = tetrahydrofurane; B = CCI,; C = CDCI,; D = Me2SO; E = CHCI,; F = CS,; G = CF,CO,H. 5Hz. 'Me(2). Me(4) not quoted. Me(1). 0 HzMe(3). 6 in ppm measured from TMS. 119;R' = R2= Me, Y = C(0H)NHCOPh. 14 - -n - - - - - - Others - ArH 14 14 74 74 74 74 Ref. H(1) masked by ArH. COMe. Me of Et group. 5 Hz. Vinyl H(2). CH,. his signal may be interchanged with M a . " Vinyl H(1). ' H(8).