Bioinorganic Medicinal Chemistry by Enzo Alessio

By Enzo Alessio

This booklet provides a complete evaluation approximately medicinal inorganic chemistry. issues like focusing on techniques, mechanism of motion, Pt-based antitumor medications, radiopharmaceuticals are lined intimately and supply the reader an in-depth review approximately this crucial subject.

Show description

Read or Download Bioinorganic Medicinal Chemistry PDF

Similar industrial & technical books

Instrument Engineers' Handbook, Volume 1, Fourth Edition: Process Measurement and Analysis

Unsurpassed in its assurance, usability, and authority for the reason that its first ebook in 1969, the three-volume device Engineers' instruction manual is still the best reference for tool engineers around the globe. It is helping clients decide upon and enforce 1000's of size and keep an eye on tools and analytical units and layout the main affordable technique keep watch over platforms that optimize construction and maximize defense.

The Static and Dynamic Continuum Theory of Liquid Crystals: A Mathematical Introduction

Given the frequent curiosity in macroscopic phenomena in liquid crystals, stemming from their purposes in monitors and units. the necessity has arisen for a rigorous but obtainable textual content compatible for graduate scholars, no matter what their medical heritage. This publication satisfies that desire. The method taken during this textual content, is to introduce the fundamental continuum conception for nematic liquid crystals in equilibria, then it proceeds to basic program of this concept- particularly, there's a dialogue of electric and magnetic box results which offer upward thrust to Freedericksz transitions, that are very important in units.

Pulp and Paper Industry: Microbiological Issues in Papermaking

Pulp and Paper undefined: Microbiological concerns in Papermaking beneficial properties in-depth and thorough insurance of microbiological matters in papermaking and their results and the present kingdom of the several possible choices for prevention, remedy and regulate of biofilm/slime contemplating the impression of the particular technological adjustments in papermaking at the keep an eye on programmes.

Homo- and Heterobimetallic Complexes in Catalysis: Cooperative Catalysis

The sequence subject matters in Organometallic Chemistry offers severe overviews of analysis leads to organometallic chemistry. As our knowing of organometallic constitution, homes and mechanisms raises, new methods are opened for the layout of organometallic compounds and reactions adapted to the wishes of such different components as natural synthesis, clinical study, biology and fabrics technology.

Extra resources for Bioinorganic Medicinal Chemistry

Example text

78]. Sodium tungstate (Na2WO4 Á 2H2O) is a novel agent in the treatment of obesity. 12 Structure of bis(2-ethyl-3-hydroxy-4-pyronato) oxovanadium(IV) (BEOV) which is in Phase II trials for treating diabetes. Metal Chelating Agents adiposity without modifying caloric intake, intestinal fat absorption, or growth rate in obese rats [79]. Sodium tungstate reduces glycemia and reverts the diabetic phenotype in several induced and genetic animal models of diabetes. Importantly, tungstate has also shown promise as an effective treatment for diabetes.

O’Halloran et al. [208] have shown that liposomal encapsulated (100 nm-scale) nanoparticles of, for example, CoII or NiII arsenite allow pH-controlled release of active drug. Folate-targeted liposomes potentiate As2O3 efficacy in relatively insensitive solid tumor-derived cells [209]. 11 Copper The potential for use of copper complexes as anticancer agents has yet to be fully exploited [210–212]. Mixed chelate copper(II) complexes (known as Casiopeı´nas) with general formulae [Cu(N-N)(a-L-amino acidato)](NO3) and [Cu(N-N)(O-O)](NO3), where the N-N donor is an aromatic substituted diimine [1,10-phenanthroline (phen) or 2,2u-bipyridine (bpy)] and the O-O donor is acetylacetonate (acac) or salicylaldehydate (salal), are in preclinical development as antineoplastic agents.

The loss of cytotoxicity in complexes of this type when XY ¼ phenanthroline or bipyridine, both strong p-acceptor ligands, is intriguing; in the case of bipyridine activity can be restored by 3,3u-hydroxylation of the rings [172]. Use of another strong p-acceptor chelating ligand hydroxy- or N,N-dimethyl-phenylazopyridine, Z ¼ iodide, leads to hydrolytically inert complexes that appear to kill cancer cells by a different mechanism: catalysis of glutathione oxidation and production of reactive oxygen species (ROS) in cells [173].

Download PDF sample

Rated 4.62 of 5 – based on 12 votes