By Enzo Alessio
This booklet provides a complete evaluation approximately medicinal inorganic chemistry. issues like focusing on techniques, mechanism of motion, Pt-based antitumor medications, radiopharmaceuticals are lined intimately and supply the reader an in-depth review approximately this crucial subject.
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78]. Sodium tungstate (Na2WO4 Á 2H2O) is a novel agent in the treatment of obesity. 12 Structure of bis(2-ethyl-3-hydroxy-4-pyronato) oxovanadium(IV) (BEOV) which is in Phase II trials for treating diabetes. Metal Chelating Agents adiposity without modifying caloric intake, intestinal fat absorption, or growth rate in obese rats . Sodium tungstate reduces glycemia and reverts the diabetic phenotype in several induced and genetic animal models of diabetes. Importantly, tungstate has also shown promise as an effective treatment for diabetes.
O’Halloran et al.  have shown that liposomal encapsulated (100 nm-scale) nanoparticles of, for example, CoII or NiII arsenite allow pH-controlled release of active drug. Folate-targeted liposomes potentiate As2O3 efﬁcacy in relatively insensitive solid tumor-derived cells . 11 Copper The potential for use of copper complexes as anticancer agents has yet to be fully exploited [210–212]. Mixed chelate copper(II) complexes (known as Casiopeı´nas) with general formulae [Cu(N-N)(a-L-amino acidato)](NO3) and [Cu(N-N)(O-O)](NO3), where the N-N donor is an aromatic substituted diimine [1,10-phenanthroline (phen) or 2,2u-bipyridine (bpy)] and the O-O donor is acetylacetonate (acac) or salicylaldehydate (salal), are in preclinical development as antineoplastic agents.
The loss of cytotoxicity in complexes of this type when XY ¼ phenanthroline or bipyridine, both strong p-acceptor ligands, is intriguing; in the case of bipyridine activity can be restored by 3,3u-hydroxylation of the rings . Use of another strong p-acceptor chelating ligand hydroxy- or N,N-dimethyl-phenylazopyridine, Z ¼ iodide, leads to hydrolytically inert complexes that appear to kill cancer cells by a different mechanism: catalysis of glutathione oxidation and production of reactive oxygen species (ROS) in cells .