Biological Weapons Defense: Infectious Disease and by Luther E. Lindler, Frank J. Lebeda, George Korch

By Luther E. Lindler, Frank J. Lebeda, George Korch

Well known specialists in biodefense research-many from the united states military clinical examine Institute of Infectious Diseases-authoritatively delineate the universe of clinical, scientific, and felony matters dealing with the biodefense study neighborhood. relating to scientific countermeasures and decontamination, the authors describe the therapy and pathogenesis of numerous confirmed pathogens (anthrax, plague, smallpox, Brucellosis, Glanders, and Coxiella burnettii) and evaluate what's identified concerning the aerosol course of an infection and decontamination tactics. in addition they research how you can realize the presence of those brokers, or different formerly unknown organic guns, and aspect the continued efforts to counter those brokers, together with proteomic and genomic research as a gateway to raised diagnostics, therapeutics, vaccinations, genotyping, and forensics. extra chapters talk about the improvement and use know-how to spot and signify those infectious organisms, rising threats, and the improvement of countermeasures.

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This program is in the process of downselecting from several of competing PCR-based technologies to develop and field a device known as the Joint Biological Agent Identification and Diagnosis System (JBAIDS). It will develop, validate, and field 8–10 gene probes and primers for PCR diagnosis of biological threat agents. JBAIDS will provide US forces with a reusable, portable, and modifiable diagnostic device capable of simultaneous, reliable identification of multiple biological organisms from appropriate clinical samples.

The simultaneous infection of those exposed to an infective agent dose would be the primary result, with potential reaerosolization of a persistent biological agent possibly leading to more exposures and infections. A recent example of the potential for a biological agent to become a persistent health threat occurred when anthrax spore-laden envelopes passed through postal service mail sorter machinery in Washington, DC. The pressure on the envelopes from the mail handling processors forced anthrax spores through unsealed portions of the envelope and resulted in numerous of infections in postal workers at the facility (3).

One wake-up call to purposeful food contamination with an infectious disease pathogen occurred in 1984 in The Dalles, Oregon. The perpetrators of this crime sprayed Salmonella typhimurium in salad bars (7). The desired outcome was to influence an election by causing illness among voters, thereby causing them not to vote. This clearly meets the definition of a bioterrorist’s objectives (5). A second example occurred in Texas in 1996, when another food-borne pathogen, Shigella dysenterae, was used in the contamination of pastries given to coworkers at a laboratory (8).

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