Biophysics: An Introduction by Roland Glaser (auth.)

By Roland Glaser (auth.)

Biophysics is the technological know-how of actual ideas underlying all approaches of lifestyles, together with the dynamics and kinetics of organic systems.

This absolutely revised 2nd English version is an introductory textual content that spans all steps of organic association, from the molecular, to the organism point, in addition to affects of environmental elements. in keeping with the big growth lately made, specially in theoretical and molecular biophysics, the writer has up-to-date the textual content, integrating new effects and advancements relating protein folding and dynamics, molecular elements of membrane meeting and shipping, noise-enhanced techniques, and photo-biophysics. The advances made in theoretical biology within the final decade demand a completely new notion of the corresponding sections. hence, the e-book offers the historical past wanted for basic education in biophysics and, additionally, bargains loads of complicated biophysical knowledge.

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Erwin Schr€odinger (1944) called the biological structure an aperiodic crystal. This means a highly organized structure, the elements of which, are not simply repeated periodically. Sometimes one tries to evaluate this structural organization as structural information. As we pointed out in the previous Sect. 2, however, it is hard to quantify this parameter. Probably, the structural information should be measured as the effort which is necessary, to describe such a structure perfectly. Consequently, the process of structure formation of biological systems, be it the development of life, its reproduction, or simply the biosynthesis of a macromolecule, all are accompanied by reduction of entropy.

9) This equality of the kinetic energy of all molecules, in fact, is a highly improbable state. In this case, using Fig. 1, all molecules would belong to a single box, or a single class of properties ni. Thus, according to Eq. /ni! ¼ 1. This situation will change instantaneously. The molecules would exchange their energy by elastic collisions with each other, and soon a great number of energy states would be occupied. A simple mathematical example shows that W, and according to Eq. 10) i¼1 The energy of this system, therefore, can be distributed randomly among all of its molecules.

The mean time of stability (t) of a molecule is inversely proportional to the rate of its transformation. 29) This equation contains a time constant (t), similar to the value A in Eq. 17. This factor depends on a number of structural properties of the molecule. It can only roughly be estimated in orders of magnitude. For smaller molecules, t will lie between 10À14 and 10À13 s. 29) are illustrated in Fig. 7. Semi-logarithmic plotting (lnt against ED) will result in a straight line. It can be clearly seen that even small changes of the activation energy (ED) of the decomposition reaction will lead to dramatic changes of the life span (t).

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