By Todd A. Swanson M.D. Ph. D, Sandra I. Kim MD PhD, Marc J. Glucksman PhD
Completely up-to-date for its 5th version, this well known assessment publication is a wonderful relief for USMLE Step 1 practise and for coursework in biochemistry, molecular biology, and genetics. Chapters are written in an overview layout and contain pedagogical good points corresponding to bolded key phrases, figures, tables, algorithms, and highlighted medical correlates. USMLE-style questions and solutions keep on with every one bankruptcy and a accomplished examination seems on the finish of the e-book. A significant other web site contains an interactive query financial institution with questions from the e-book and the absolutely searchable textual content.
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Additional resources for BRS Biochemistry, Molecular Biology, and Genetics, Fifth Edition (Board Review Series)
3. 3. a. These interactions are between the carbonyl of one peptide bond and the –NH of another. b. The chains may run in the same direction (parallel) or in opposite directions (antiparallel). 23 24 Biochemistry, Molecular Biology, and Genetics Secondary Primary Ser Ala Glu Val Leu Arg Gly α-helix β-sheet Quaternary Tertiary Subunit 2 Subunit 1 FIGURE 1-1 Schematic diagram of the primary, secondary, tertiary, and quaternary structure of a protein. O H Cα R O C H N H C Cα Cα O N H R R N C H H O Cα H R O C N H O C Cα H H R N Cα C H N H O R Cα R H C N O H Cα H C R O H N Cα H O C R N H Cα C H R N H Cα R H FIGURE 1-2 An a-helix.
These fibrils accumulate in tissue, often resulting in worsening pathology as the amyloid accumulates. See Table 1-1 for some clinically relevant amyloidopathies. CLINICAL CORRELATES Mutations in patients with a1-antitrypsin (AAT) deficiency result in a misfolded protein that gets trapped within the cell. Patients with decreased levels of this protease inhibitor manifest with cirrhosis and emphysema. Chapter 1 t a b l e 1-1 Protein Structure and Function 27 Amyloidosis and Human Disease Amyloid Protein Component Associated Disease Notes b-amyloid Alzheimer disease b2-microglobulin Calcitonin Hemodialysis-associated amyloidosis Medullary carcinoma of the thyroid Immunoglobulin light chain Multiple myeloma Islet amyloid protein Type 2 diabetes mellitus The most common cause of progressive dementia Deposition of amyloid in bone joints results in arthritis and cartilage and bone destruction.
A. Some are involved in the transport of substances across the membrane. CLINICAL CORRELATES The cystic fibrosis transmembrane regulator (CFTR) is a chloride ion channel found on cell membranes. Mutation in this protein (the most common of which is the loss of a phenylalanine residue at position 508, known as the DF508 mutation) results in cystic fibrosis (CF). CF is the most common lethal genetic disease in Caucasians and results in viscous secretions of the respiratory tract with recurrent life-threatening pulmonary infections.