By Michael A. Lieberman, Rick Ricer
BRS Biochemistry, Molecular Biology, and Genetics is a superb reduction for USMLE Step 1 training and for coursework in biochemistry, molecular biology, and genetics. totally up-to-date for its 6th variation, chapters are written in an summary structure and comprise pedagogical beneficial properties similar to bolded key phrases, figures, tables, algorithms, and highlighted medical correlates. USMLE-style questions and solutions keep on with every one bankruptcy and a accomplished examination looks on the finish of the ebook.
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Extra info for BRS Biochemistry, Molecular Biology, & Genetics (Board Review Series) (6th Edition)
3. Irreversible inhibitors bind tightly to the enzyme and inactivate it. Clinical Drugs are frequently used therapeutically to inhibit enzymes; for example, Correlates 5-fluorouracil (5-FU) is used to inhibit the enzyme thymidylate synthetase. This enzyme converts dUMP to dTMP, which ultimately provides the thymine for DNA synthesis. 5-FU is used as a chemotherapeutic agent to inhibit the proliferation of cancer cells. Aspirin irreversibly inhibits the enzyme cyclooxygenase, and interferes with the generation of prostaglandins and thromboxanes, the secondary mediators of pain signaling.
Many of these oxidations are reversed by reductions. b. In oxidation reactions, electrons are lost. In reduction reactions, electrons are gained. c. As foods are oxidized, electrons are released and passed through the electron transport chain. Adenosine triphosphate (ATP) is generated, and it supplies the energy to drive various functions of the body. II. Acids, Bases, and Buffers •• Many biochemical compounds, ranging from small molecules to large polymers, are capable of releasing or accepting protons at physiologic pH, and as a consequence, may carry a charge.
Oxidations of sulfhydryl groups to disulfides, of alcohols to aldehydes and ketones, and of aldehydes to carboxylic acids frequently occur. a. Many of these oxidations are reversed by reductions. b. In oxidation reactions, electrons are lost. In reduction reactions, electrons are gained. c. As foods are oxidized, electrons are released and passed through the electron transport chain. Adenosine triphosphate (ATP) is generated, and it supplies the energy to drive various functions of the body. II.